The 3 Levels of Inflammation Health    Throughout your life, unseen forces are shaping your health. As most people age, they usually progress through three distinct phases of health. To succeed in weight loss programs and diets, you absolutely must understand the three levels of health.    You start life in Level 1, which is a non-inflammation, non-insulin resistant state. Your body is able to maintain homeostasis -- your metabolism adjusts itself to maintain a steady weight and to fight diseases automatically. You look and feel good.    As you encounter infections and eat the wrong foods, you lose your ability to maintain a healthy balance. Infections could be similar to today's Bird Flu (H5N1) Asian Influenza, measles, mumps, pneumonia, the common cold, gum or tooth infections or a sinus problem. Inflammation increases each time you suffer one of these infections or eat high levels of sugars or "bad fats".    Each time you become inflamed, you struggle to get back to normal. But sometimes, you don't quite go all the way back. Your body "remembers" your infection and increases its "ready reserve" of inflammatory cytokines, keeping your system on a knife-sharp edge of readiness. Unfortunately, while being constantly ready for infection helps you survive the next infection, it exerts terrible wear-and-tear on your body's delicate tissues and interferes with the smooth functioning of many metabolic systems. Gradually, you move into Level 2, which is chronic low-level inflammation and insulin resistance.    Level 2 involves a powerful chain reaction of mutually reinforcing metabolic processes. Infection produces inflammation. Inflammation produces insulin resistance. Insulin resistance produces weight gain. Weight gain produces inflammatory cytokines leading to more insulin resistance.    Insulin resistance starves our muscles, which react by sending messages that lower our resting energy expenditure to conserve our reserves and then, the insulin resistance makes us hungry in an effort to feed our starving muscles. Under these conditions, weight loss is almost impossible. We look "fat" to others, but our muscles think we're starving... at least chemically. Due to this process, grossly fat people are in fact starving. As a result of this starvation, we eat more sugars, simple starches and fats to add to our disease, while preventing or slowing weight loss inspite of your dieting efforts.    As these conditions worsen, you finally begin to exhibit obvious diseases of Level 3 -- cardiovascular diseases, diabetes, hypertension, Alzheimers, arthritis, stroke, cancer... To that list add acne vulgaris, multiple sclerosis, muscular dystrophy, benign prostatic hyperplagea, polycystic ovary disease, chronic headaches, cluster and migraine headaches, skin tags, many auto-immune diseases and so on. It's a big list.    The goal of the Level1Diet.com and the Food Guide Football™ is to return you to Level 1 ...		The Level1Diet.com Food Guide Football™ Anti-Inflammation Program    The original FDA Food Guide Pyramid from 1992 is dead. It has been discarded finally by the FDA themselves. It was changed repeatedly to accommodate new research, and in 2005 it was updated with a new "sliding scale" dietary approach called My Pyramid. A consumer research study performed by the USDA among consumers from 2002 to 2004 proved that most people are still confused about the Food Guide Pyramid. People are unclear about what to eat and why it's good for them. Today, the Pyramid approach remains confusing and unhelpful for most people. Consumers are not sure about serving sizes, and relative proportions of different types of food to include in their diet. Scientists continue to argue about the actual details of the food approaches that ought to be recommended. Even the newer MyPyramid System remains controversial. The confusion and outright incorrect thinking behind the Food Guide Pyramid persists in many nutritional circles.    To replace the pyramid, we have developed a simple, easy to understand pictographic meal plan called the Food Guide Football™.    When we studied the kinds and amounts of foods that should be eaten on the state-of-the-art anti-inflammation diet, we found an interesting fact... they fit roughly into the shape of a traditional American football.    The football shape helps us show you what proportions the different kinds of food to place on your plate through the day. It is a relative size or layout of the foods on the plate -- the way you naturally see them when you sit at the table.    At the one small end are the "good fats" -- virgin olive oils and virgin coconut oils. Small servings of simple sugars and starches are minimized in the other small end.    Inside one white stripe are proteins from vegetables like beans, peas, nuts and seeds. The other stripe represents lean cuts of chicken, turkey, grass-fed beef or wild fish.    Finally, in the big central area are colorful, high antioxidant, high fiber, complex carbohydrates with a low glycemic index. The legal food list includes hundreds of fresh or frozen vegetables and fruits.    Antioxidant spices like ginger, cinnamon, turmeric, chile, cayenne and many herbs are powerful allies in the battle against inflammation. Green and brown teas are high on the list.    Let's get into the deadly serious anti-inflammation game. Are you ready for some football? ...	Click to See Studies From Peer Reviewed Scientific Journals Supplements Proven to Increase Series-1 & 3 Anti-Inflammation Prostaglandins Fish Oil, EPA 24-25,34-35 Borage Oil, GLA 26-33 Sesame Seed Lignans 41 Supplements Proven to Block Pro-Inflammation Cytokines Green Tea 4-9 Magnesium 10-12 N-Acetyl-Cysteine 36-38 Nettle Leaf Extract 39-40 Vitamins K1, K2 42 Bromelain, Pineapple 13 Pomegranate Extract 14 SAMe 15 Brown Tea 16 Papaya Seed Extract 17 Milk Thistle 18 Indian Celery Seed 19 Green-Lipped Mussel 20 Turmeric, Curcumin 21 Golden Seal 22 Aspirin 23 Acetaminophen 23
How Infection & Diet Leads to Obesity & Diseases    Weight Loss diets generally fail, not because people don't work at them, but because they are not given enough information to understand what they need to do and why. Most people started gaining weight while they were still young and vigorous.    Until recently, many authorities thought weight gain always resulted from "overeating" or "lack of exercise". They thought weight loss happened only when we simply eat less. This thinking is now known to be incorrect. While weight loss is possible when we eat less, it is much easier when eating less also includes avoiding certain kinds of pro-inflammatory foods. Eating inflammatory foods cause us to gain weight. Weight loss is almost impossible for most people until they stop eating inflammatory foods like omega-6 vegetable oils, saturated fats from farm raised animals and trans fats from processed foods, as well as cut way down on concentrated high fructose sugars and sweeteners.    Overeating and low energy expenditure is the result, not the cause of obesity.    We now know that obesity often develops among people who are eating the same amount of total calories as people do who stay thin.    Three factors make the difference; their genetic heritage (especially related to D6D/D5D enzymes), the KIND OF FATS and KINDS OF CARBOHYDRATES they eat instead of the amounts, and the infections they have suffered from ...		Fatal Diseases Related to Inflammation    Over 73% of Americans end up dying from only a few diseases -- heart disease, cancer, stroke, diabetes, Alzheimers, hypertension or liver and kidney diseases.    Scientific studies published in peer reviewed journals are now revealing that persistent low-level inflammation and insulin resistance (metabolic syndrome x) are associated with these diseases.    Searching the online government health databases reveals some shocking truths that your physician himself may not know about; weight loss or weight gain, inflammation and insulin resistance lay the foundation for almost every major disease in America.    Improving inflammatory conditions and lowering your insulin resistance can prevent or reverse these diseases for many people. Making the transition is relatively easy -- follow our Food Guide Football™ on the Level1Diet.com health program ...
Supplements to Reduce Low-Level Inflammation & Lower Insulin Resistance    Eating a proper diet based on our Food Guide Football™ anti-inflammation food list is the first step in reducing risks of heart disease, stroke, cancer, diabetes and other degenerative diseases.    However, overcoming chronic inflammation is a big job, requiring several important nutritional supplements to reduce inflammatory conditions and lower insulin resistance. The list includes Fish Oil, Borage Oil, Magnesium, Green Tea, Vitamin-C, Vitamin-E ...
How Omega-3 Fish Oil & Omega-6 Borage Oil Reduce Persistent Low-Level Inflammation    Up to 80% of Americans do not have enough of the critically important digestive enzyme D6D delta-6 desaturase to maintain health or for weight loss.    D6D deficiency is known to result from a range of factors, including their genetic heritage, too much sugar, too much animal fat, and too much omega-6 vegetable oil in their diet, environmental pollutants, and lifestyle habits like smoking, drinking alcohol, etc. As a result, their D5D delta-5 desaturase enzyme converts vegetable oils into AA arachidonic acid.    Excessive amounts of AA results in over-production of pro-inflammatory PGE-2 series-2 prostaglandins. This slows weight loss and in fact, leads to weight gain, obesity, heart disease, cancer, diabetes, stroke and other diseases associated with low-level chronic inflammation.    You are probably in that 80% suffering from functional D6D deficiencies. D6D is needed to digest Alpha Lenolenic Acid and Lenoleic Acid from omega-6 (corn, soybean, safflower, sunflower etc.) and omega-3 (flax, walnut, perilla) vegetable oils. Some fish and plants can do the D6D work for you. When you take fish oil and borage oil, you overcome your dysfunctional D6D and get nutrients needed to build anti-inflammatory prostaglandin series 1 and 3, which enables weight loss ...

How the Level 1 Diet Works: Foods Eat & Avoid, Supplements to Take, and How to Exercise

THE LEVEL 1 DIET Step #1 Foods to Avoid Step #2 Foods to Eat Step #4 Moderate Daily Exercise Step #3 Supplements to Take

Are You at Level 1?

There are 3 levels of health: Level 1 Health is the youthful, vigorous state of health we were born with. Weight loss isn't needed, because we aren't overweight. Scientists would call that a homeostatic condition, where your body can maintain itself properly. Homeostasis is a condition of each process in our body being properly balanced against another. In that desirable state, we are at equilibrium. It should be the goal of any approach to health to maintain us at level 1, and if we have, like most people wandered away. The goal of any health approach should be to return to Level 1.

Level 2 Health is where our body slowly loses its ability to maintain homeostasis. The body falls into a self reinforcing pattern of inflammatory chain reactions that lead to discomfort, lethargy, pain and dysfunction; a loss of homeostasis. Our body becomes "out of balance", primarily due in most cases to low levels of persistent inflammation. Weight loss is very difficult in this condition. We now know that chronic low-level inflammation is caused mainly by our unnatural modern diet (which we CAN control), together with some hereditary and environmental factors (which we often CANNOT control).

So, we focus on factor that we can control, namely our diet and lifestyle. Our unhealthy diet, that leads to levels 2 and 3, is known and studied by scientists under by many names; such as the HFHS high-fat high-sugar diet, or the HFHSLF high fat high sugar low fiber diet, or simply the "American diet" or the "western diet". This disastrous diet consists of fried and other high fat foods like ice cream or mayonnaise, high sugar foods such as candies, sweet drinks, pastries, pies and cakes, low fiber meals of highly processed vegetables and meats, and very little fresh fruit, whole grains or nuts.

As your health declines in Level 2, you usually gain weight -- a few pounds a year or more. Even though you may go on every diet plan in the country, you find permanent weight loss impossible. While you become slowly obese, other health factors also deteriorate; your blood pressure increases, your arteries become partially clogged with plaques, your hormone levels become erratic, resulting in sleep disorders, moodiness, depression and sexual dysfunction.

Poor control of blood sugar results from growing insulin resistance in your liver and muscle cells. Weight loss slows under these conditions. High levels of blood glucose after meals causes a sleepiness in mid-mornings and afternoons; hence the famous "2 o'clock slump" (from high blood sugar) in your workday, followed by the "4 o'clock munchies" (from low blood sugar). Your system compensates against the 2 o'clock slump's high blood sugar levels by releasing massive amounts of insulin, which scavenges every last bit of sugar out of your blood, sending you into the the 4 p.m. munchies, or an eating binge at dinner time. This results in more sleepiness or foggy headiness about bed time. However, like the evening low-blood-sugar hypoglycemia, you develop a 4 a.m. hypoglycemia while you are still asleep. This results in a release of adrenaline as your body tries to get you into "hunter mode" to give it something to balance the low blood sugar, to feed your starving brain the glucose it runs on. The adrenaline rush causes a panic attack, which wakens you in the early pre-dawn hours. You leap from bed in a rush of worry, concern, and panic. You eat whatever is handy; usually something sweet. Then you may find yourself going back to bed again just about the time you need to be getting up for work. Whoops! Weight loss? Forget it!

In every aspect, you are losing control of your body's systems and processes. Many of your internal organs become less efficient, including your heart, kidneys, liver and pancreas. Any weight loss program you were working at slows to a crawl. Despite dieting, you may actual gain weight. You become lethargic due to a malfunctioning metabolism. Your productivity at work decreases, while mood swings (caused by hormone imbalances) make your family and personal life deteriorate. Level 2 health unfortunately, usually goes noticed by either you or your health professionals. When noticed or treated, Level 2 conditions are generally treated merely as one isolated problem, rather than a symptom of a much broader overall decline in health. As a result of this episodic or hit-or-miss approach, most of us continue our progress into a much worsened condition. Despite occasional treatment for this or that specific condition, our chronic low-level inflammatory disease persists and worsens. Finally, our health decline accelerates until we go into the final health status; Level 3.

Level 3 Health is a state of full, obvious and frank, overt disease. Declining level 2 conditions usually result in a true crisis, which leads to medical treatment by doctors and hospitals. It could be a heart attack, stroke, diabetic coma, runaway infection, liver or kidney disease, or even a serious personality disorder, among many others. These level 3 crisis treatments often return us to level 2, but almost never result in a return to level 1. Without insight into what causes the decline from level 1 health into levels 2 and 3, you may continue to live your life the same way that produced your ultimate crisis. We exist to help you understand what caused your retreat from a healthy, vigorous, youthful Level 1. Armed with that knowledge, you will take simple, easy steps to immediately begin your journey back, following healthful paths. In a matter of only a few days using our Level 1 Diet approach, you will notice lessened food cravings, reductions in aches and pains, better sleeping, and more energy during work or play. Then, as you continue to follow the principles outlined here, you will begin to notice steady and dramatic weight loss, increased productivity at work accompanied by more joy during rest and play, improved alertness, reduced moodiness and increases your in energy levels. Is that too much to expect? No, it's merely the vigor, joy and healthy energy of your youth. While we can't turn back the calendar in the outside world, most of us can eventually return to Level 1 Health and turn back the clock of our internal calendar, if we follow the principles of the Level 1 Diet.

Only You Can Change Your Life!

By the time you get to the final stages of advancing disease, you will need to turn to doctors and hospitals for help in managing your health. They are a vital part of the process of dealing with Level 2 and Level 3 problems. However, it is important to recognize that only you can manage your own life. Only you can do the tough daily work of running your weight loss or health optimizing program. You must take charge. Read, think, ask, and do. Read about health. Think about how it applies to your own particular life. Ask for help from health professionals, friends and family. Let others know what you are doing and ask for their cooperation and their help. Then do the right thing. No matter how much other people know, or how much they may love you, only YOU can change your life. The good news is that it can be much easier than you ever imagined. Dramatic health improvements can be achieved. You can move toward vigorous, joyful health. The ancient sage said "The journey of a thousand miles begins with only one step!" Your own journey can begin right now. Take that first step... step into the Level 1 Diet and change your life.

About the Level 1 Diet

Level1Diet.com supports an anti-inflammation weight loss diet program that restricts inflammatory omega-6 oils and trans-fats, increases anti-inflammatory omega-3 foods such as certain oily fish and some whole nuts, emphasizes high fiber vegetables and antioxidant fruits, and supplements with daily vitamins, minerals, herbs and plant extracts. Weight loss and optimum weight management are the result of following the diet. Our goal is to lose weight and to reverse or reduce risks for the major diseases associated with chronic inflammation; heart disease, cancer, stroke, diabetes, Alzheimer's, and many other degenerative conditions. The Level 1 Diet features an ad libitum approach to dieting using the physical size or portions of food on the plate, rather than a calorie counting or percentage of macro nutrient system. The relative proportions of food in our system fit roughly into the shape of an American Football, with vegetables, fruits, fish, beens and nuts taking up the large central parts of the ball, and less desirable but necessary higher fats, and high glycemic index sugary or starchy foods at the smaller ends of the ball.

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References

1. "A nucleotide insertion in the transcriptional regulatory region of FADS2 gives rise to human fatty acid delta-6-desaturase deficiency", Journal of Lipid Research, Vol. 44, 2311-2319, December, 2003.
   
2. "Identification of a fatty acid {Delta}6-desaturase deficiency in human skin fibroblasts", Journal of Lipid Research, Vol. 42, 501-508, April, 2001.
   
3. "Suspected faulty essential fatty acid metabolism in Sjogren-Larsson syndrome", Pediatric Research, Vol 16, 45-49, 1982.
   
4. "Green tea with a high catechin content suppresses inflammatory cytokine expression in the galactosamine-injured rat liver", Biomedical Research (Tokyo, Japan) 2005 Oct;26(5):187-92.
   
5. "More tea for septic patients? - Green tea may reduce endotoxin-induced release of high mobility group box 1 and other pro-inflammatory cytokines", Medical Hypotheses, 2006;66(3):660-3. Epub 2005 Nov 2.
   
6. "Immune cell activation and subsequent epithelial dysfunction by Staphylococcus enterotoxin B is attenuated by the green tea polyphenol (-)-epigallocatechin gallate" (EGCG from Green Tea), Cellular Immunology, 2005 Sep;237(1):7-16. Epub 2005 Oct 6.
   
7. "Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells" (ECG from Green Tea), Carcinogenesis, Volume 25, Number 12, Pp. 2425-2432.
   
8. "Green Tea Polyphenol Epigallocatechin-3-gallate (EGCG) Differentially Inhibits Interleukin-1{beta}-Induced Expression of Matrix Metalloproteinase-1 and -13 in Human Chondrocytes" (EGCG from Green Tea), Journal of Pharmacology And Experimental Therapeutics Fast Forward, November 4, 2003; DOI: 10.1124/jpet.103.059220.
   
9. "Comparative effects of polyphenols from green tea (EGCG) and soybean (genistein) on VEGF and IL-8 release from normal human keratinocytes stimulated with the proinflammatory cytokine TNFalpha" (EGCG from Green Tea), Archives of Dermatological Research, 2003 Jul;295(3):112-6. Epub 2003 Jun 13.
   
10. "Magnesium Intake, C-Reactive Protein, and the Prevalence of Metabolic Syndrome in Middle-Aged and Older U.S. Women", Diabetes Care 28:1438-1444, 2005, a publication of The American Diabetes Association.
    
11. "Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X", Molecular Aspects of Medicine, 24:39-52, 2003.
    
12. "Magnesium Replacement Therapy", The American Family Physician, 1990;42:173-6..
    
13. "Bromelain (pineapple extract) as a Treatment for Osteoarthritis: a Review of Clinical Studies", Evidence Based Complementary and Alternative Medicine, 2004 December; 1(3): 251-257.
    
14. "Punica granatum L. (pomegranate fruit) extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro", The Journal of Nutrition, 2005 Sep;135(9):2096-102.
    
15. "S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial", BMC Musculoskeletal Disorders, February 26, 2004; 5: 6.
    
16. "Tannic Acid Is an Inhibitor of CXCL12 (SDF-1{alpha})/CXCR4 with Antiangiogenic Activity", Clinical Cancer Research Vol. 9, 3115-3123, August 2003.
    
17. "Possible immunomodulatory actions of Carica papaya seed extract", Clinical Hemorheology and Microcirculation 2003;29(3-4):219-29.
    
18. "Silymarin (milk thistle extract) and skin cancer prevention: anti-inflammatory, antioxidant and immunomodulatory effects (Review)", International Journal of Oncology, 2005 Jan;26(1):169-76.
    
19. "Combination anti-inflammatory therapy: synergism in rats of NSAIDs/corticosteroids with some herbal/animal products" (Indian Celery Seed & New Zealand Green-Lipped Mussel), Inflammopharmacology. 2003;11(4):453-64.
    
20. "Systematic review of a marine nutriceutical supplement in clinical trials for arthritis: the effectiveness of the New Zealand green-lipped mussel Perna canaliculus", Clinical Rheumatology, 2005 Oct 12;:1-10.
    
21. "Caffeic Acid Phenethyl Ester and Curcumin: A Novel Class of Heme Oxygenase-1 Inducers", Molecular Pharmacology, Vol. 61, Issue 3, 554-561, March 2002.
    
22. "Anticachectic effects of Coptidis rhizoma, an anti-inflammatory herb, on esophageal cancer cells that produce interleukin 6" (Goldenseal), Cancer Letters, 2000 Sep 29;158(1):35-41.
    
23. "Modulators of prostaglandin E2 synthesis in human amnion" (Aspirin, Acetaminophen), Journal of the Society Gynecologic Investigation, 1994 Apr-Jun;1(2):131-4.
    
24. "Antagonists and inhibitors of lipid mediators in experimental inflammation of the cornea" (Fish Oil EPA/DHA), Journal of Ocular Pharmacology, 1993 Winter;9(4):365-72.
    
25. "The effect of dietary fish oil supplement upon the content of dihomo-gammalinolenic acid in human plasma phospholipids" (Large doses of EPA reduce DGLA, suggesting use of Borage Oil with Fish Oil), Prostaglandins, Leukotrienes and Essential Fatty Acids. 1990 May;40(1):9-12.
    
26. "Importance of Dietary Gamma-Linolenic Acid in Human Health and Nutrition" (Sources of GLA: Borage Oil, Black Currant Oil, Evening Primrose Oil), The Journal of Nutrition, Vol. 128 No. 9 September 1998, pp. 1411-1414.
    
27. "Evening primrose oil and borage oil in rheumatologic conditions" (Sources of GLA), American Journal of Clinical Nutrition, Vol. 71, No. 1, 352S-356s, January 2000.
    
28. "Borage oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha" (Sources of GLA), International Immunopharmacology, 2001 Nov;1(12):2197-9.
    
29. "Oral administration of gammalinolenic acid, an unsaturated fatty acid with anti-inflammatory properties, modulates interleukin-1beta production by human monocytes" (Borage Oil GLA), Journal of Clinical Immunology, 2002 Mar;22(2):83-91.
    
30. "Diabetic neuropathy: pathogenesis and therapy" (Borage Oil, Source of GLA), The American Journal of Medicine, 1999 Aug 30;107(2B):17S-26S.
    
31. "Dietary Supplementation with gamma -Linolenic Acid Alters Fatty Acid Content and Eicosanoid Production in Healthy Humans" (Borage Oil, Source of GLA), The Journal of Nutrition, Vol. 127 No. 8 August 1997, pp. 1435-1444.
    
32. "Treatment of diabetic neuropathy with gamma-linolenic acid. The gamma-Linolenic Acid Multi-center Trial Group" (Borage Oil, Source of GLA), Diabetes Care. 1993 Jan;16(1):8-15.
    
33. "The effect of gamma-linolenic acid on human diabetic peripheral neuropathy: a double-blind placebo-controlled trial" (Borage Oil, Source of GLA), Diabetic Medicine: A Journal of the British Diabetic Association, 1990 May;7(4):319-23.
    
34. "Differential effects of prostaglandin derived from w-6 and w-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion" (Fish Oil, Source of EPA/DHA), Proceedings of the National Academy of Sciences of the United States of America, 2003 February 18; 100(4): 1751-1756.
    
35. "Cellular interactions between n-6 and n-3 fatty acids: a mass analysis of fatty acid elongation/desaturation, distribution among complex lipids, and conversion to eicosanoids" (Role of Enzymes and Other Factors in Lipid Metabolism of Omega-3 vs. Omega-6 Fatty Acids), Journal of Lipid Research, 1992 Oct;33(10):1431-40.
    
36. "Trans, trans-2,4-decadienal, a product found in cooking oil fumes, induces cell proliferation and cytokine production due to reactive oxygen species in human bronchial epithelial cells" (Protective role of N-Acetylcysteine NAC), Toxicological Sciences, 2005 Oct;87(2):337-43. Epub 2005 Jul 13.
    
37. "Five Cysteine-Containing Compounds Delay Diabetic Deterioration in Balb/cA Mice" (Protective role of N-Acetyl-Cysteine NAC), The American Society for Nutritional Sciences J. Nutr. 134:3245-3249, December 2004.
    
38. "N-acetylcysteine and alpha-tocopherol reverse the inflammatory response in activated rat Kupffer cells" (Protective role of N-Acetyl-Cysteine NAC), The Journal of Immunology, 1997 Jun 1;158(11):5418-23.
    
39. "Cytokine secretion in whole blood of healthy subjects following oral administration of Urtica dioica L. plant extract" (Reduction of TNF-alpha and IL-6 by Nettle Leaf Extract, in German with English Abstract), Arzneimittelforschung. 1996 Sep;46(9):906-10.
    
40. "Ameliorative effect of IDS 30, a stinging nettle leaf extract, on chronic colitis" (Reduction of Tumor Necrosis Factor-alpha by Nettle Leaf Extract and the extension of long-term remission from inflammatory bowel disease), International Journal of Colorectal Disease, 2005 Jan;20(1):9-17. Epub 2004 Aug 25.
    
41. "Effects of sesamin and capsaicin on the mRNA expressions of delta6 and delta5 desaturases in rat primary cultured hepatocytes" (Sesame Seed Lignans - Sesamin - reduced activity of delta5 desaturase enzyme), Journal of Nutritional Science Vitaminology (Tokyo). 2003 Dec;49(6):442-6.
    
42. "Interleukin 6 production by lipopolysaccharide-stimulated human fibroblasts is potently inhibited by naphthoquinone (vitamin K) compounds", Cytokine. 1995 Apr;7(3):287-90.